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Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARα/γ activation in 3T3‐L1 cells
Author(s) -
Kim Su-Nam,
Choi Hye Young,
Lee Woojung,
Park Gab Man,
Shin Woon Seob,
Kim Yong Kee
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.011
Subject(s) - troglitazone , adipogenesis , glut4 , adipocyte , adiponectin , chemistry , resistin , peroxisome , 3t3 l1 , peroxisome proliferator activated receptor , medicine , biochemistry , insulin resistance , biology , endocrinology , microbiology and biotechnology , adipose tissue , insulin , receptor
We screened active compounds from natural marine products able to increase PPARα/γ transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) from Sargassum yezoense were identified as novel PPARα/γ dual agonists. The binding affinity of SQA with PPARγ was higher than that of the specific PPARγ agonist troglitazone, leading to an activation of PPARγ transcriptional activity. In parallel, treatment of 3T3‐L1 cells with SQA and SHQA led to an increase in adipocyte differentiation and increased expression of adipogenic marker genes such as aP2, PPARγ, resistin, adiponectin, C/EBPα and Glut4. Collectively, our data suggest that SQA and SHQA are novel PPARα/γ dual agonists and may be beneficial for reducing insulin resistance through regulation of adipogenesis.