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Wnt4 and Wnt5a promote adipocyte differentiation
Author(s) -
Nishizuka Makoto,
Koyanagi Akiko,
Osada Shigehiro,
Imagawa Masayoshi
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.08.011
Subject(s) - adipogenesis , wnt4 , wnt signaling pathway , wnt5a , microbiology and biotechnology , regulator , adipocyte , biology , phenotype , gene , genetics , endocrinology , adipose tissue , signal transduction
The roles of the non‐canonical Wnt pathway during adipogenesis are not well known, though Wnt10b is known to function as a negative regulator for adipogenesis by activating the canonical Wnt pathway. We focused on the roles of Wnt4, Wnt5a and Wnt6, which are thought to be part of the non‐canonical Wnt pathway. The expression of these genes changed dramatically at the initial stage of adipogenesis. Furthermore, the inhibition of Wnt4 or Wnt5a expression prevented the accumulation of triacylglycerol and decreased the expression of adipogenesis‐related genes. Wnt4 and Wnt5a have crucial roles in adipogenesis as positive regulators.