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The lectin‐like activity of human C1q and its implication in DNA and apoptotic cell recognition
Author(s) -
Païdassi Helena,
Tacnet-Delorme Pascale,
Lunardi Thomas,
Arlaud Gérard J.,
Thielens Nicole M.,
Frachet Philippe
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.08.001
Subject(s) - dna , lectin , protein subunit , moiety , microbiology and biotechnology , biology , chemistry , biochemistry , stereochemistry , gene
C1q, the binding subunit of the C1 complex of complement, is an archetypal pattern recognition molecule known for its striking ability to recognize a wide variety of targets, ranging from pathogenic non self to altered self. DNA is one of the C1q ligands, but the precise region of C1q and the DNA motifs that support interaction have not been characterized yet. Here, we report for the first time that the peripheral globular region of the C1q molecule displays a lectin‐like activity, which contributes to DNA binding through interaction with its deoxy‐ d ‐ribose moiety and may participate in apoptotic cell recognition.