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Bax inserts into the mitochondrial outer membrane by different mechanisms
Author(s) -
Cartron Pierre-François,
Bellot Grégory,
Oliver Lisa,
Grandier-Vazeille Xavier,
Ma Stephen,
Vallette François M.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.07.047
Subject(s) - bacterial outer membrane , translocase of the inner membrane , translocase of the outer membrane , mitochondrial apoptosis induced channel , mitochondrion , microbiology and biotechnology , mitochondrial membrane transport protein , inner mitochondrial membrane , mitochondrial carrier , cytosol , bcl 2 associated x protein , biology , membrane , chemistry , apoptosis , biochemistry , programmed cell death , gene , enzyme , escherichia coli , caspase 3
Bax insertion into the mitochondrial outer membrane is essential for the implementation of apoptosis. However, little is known about the first stage of Bax integration into the mitochondrial outer membrane. We have recently shown that TOM22, a mitochondrial outer membrane receptor, is important for insertion, although other reports have suggested that only mitochondrial lipids are involved in this process. Here, we show that monomers, but not dimers, of Bax require the presence of TOM22 and TOM40 to integrate into mitochondria. In addition we show that once inserted into the membrane, Bax can act as a receptor for cytosolic Bax.