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Structural insights into P‐glycoprotein (ABCB1) by small angle X‐ray scattering and electron crystallography
Author(s) -
McDevitt Christopher A.,
Shintre Chitra A.,
Günter Grossmann J.,
Pollock Naomi L.,
Prince Stephen M.,
Callaghan Richard,
Ford Robert C.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.07.022
Subject(s) - scattering , glycoprotein , small angle x ray scattering , crystallography , p glycoprotein , chemistry , protein structure , biochemistry , physics , multiple drug resistance , optics , antibiotics
P‐glycoprotein (ABCB1) is an ATP‐binding cassette protein that is associated with the acquisition of multi‐drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X‐ray scattering data and cryo‐electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P‐glycoprotein based on the bacterial Sav1866 structure.