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Heat shock protein 60 induces inflammatory mediators in mouse adipocytes
Author(s) -
Gülden Elke,
Mollérus Sina,
Brüggemann Jutta,
Burkart Volker,
Habich Christiane
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.07.002
Subject(s) - adipocyte , proinflammatory cytokine , cxcl1 , heat shock protein , microbiology and biotechnology , innate immune system , adipose tissue , inflammation , monocyte , regulator , chemokine , endocrinology , chemistry , medicine , biology , immunology , immune system , biochemistry , gene
Adipocytes represent an important cellular source of inflammatory mediators. However, the signals for the induction of proinflammatory adipocyte activities are largely unknown. Here, we demonstrate that heat shock protein (Hsp) 60, a potent stimulator of innate immunity, induces the release of the inflammatory mediators interleukin‐6, CXCL1 and monocyte chemoattractant protein‐1 in a time‐ and concentration‐dependent manner from cells of the adipocyte line 3T3‐L1 and from adipocytes of obese mice. These results identify Hsp60 as an important regulator of adipocyte functions which contribute to the development of inflammatory processes as observed in diabetes and diabetes‐associated complications.