The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA | Zendy

Scheffers Dirk-Jan | Zendy

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The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA

Author(s) -

Scheffers Dirk-Jan

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.06.038

Subject(s) - ftsz , bacillus subtilis , cell division , microbiology and biotechnology , polymerization , protein filament , chemistry , cytoskeleton , biophysics , biochemistry , bacteria , cell , biology , genetics , polymer , organic chemistry

The min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram‐positive bacterium, Bacillus subtilis , is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH‐dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling.

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