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Regulation of the human tRNase Z S gene expression
Author(s) -
Takahashi Masayuki,
Takaku Hiroaki,
Nashimoto Masayuki
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.06.020
Subject(s) - gene , transcription (linguistics) , biology , genetics , gene expression , promoter , transfer rna , rna , microbiology and biotechnology , philosophy , linguistics
There are two types of tRNA 3′ processing endoribonucleases (tRNase Z): a short form (tRNase Z S ) and a long form (tRNase Z L ). Although the human genome contains both genes, little is known about the physiological role of tRNase Z S . We found that the human tRNase Z S gene expression appears to be post‐transcriptionally regulated. Additionally, analyses for cis ‐regulatory elements for the tRNase Z S gene transcription suggested that transcription factors that bind to five different sites on the promoter work together to potentiate the transcription initiation. Furthermore, we found that tRNase Z S is predominantly present in the cytosol and hardly in the nucleus.