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RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors
Author(s) -
Seebahn Angela,
Rose Melanie,
Enz Ralf
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.06.010
Subject(s) - metabotropic glutamate receptor , metabotropic glutamate receptor 1 , metabotropic receptor , metabotropic glutamate receptor 6 , glutamate receptor , receptor , microbiology and biotechnology , class c gpcr , neuroscience , inner plexiform layer , metabotropic glutamate receptor 7 , neurotransmitter receptor , biology , neurotransmitter , metabotropic glutamate receptor 2 , metabotropic glutamate receptor 8 , metabotropic glutamate receptor 5 , chemistry , retina , biochemistry
In the central nervous system, synaptic signal transduction depends on the regulation of neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina. There, RanBPM is restricted to the inner plexiform layer where it co‐localizes with the mGlu8b isoform and processes of cholinergic amacrine cells expressing mGlu2 receptors. RanBPM interacts with mGlu2 and other group II and group III receptors, except mGlu6. Our data suggest that RanBPM might be associated with mGlu receptors at synaptic sites.