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Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation
Author(s) -
Lee Kyeong-Hee,
Moon Kyeong-Jin,
Kim Hyung Sik,
Yoo Byong Chul,
Park Seoyoung,
Lee Ho,
Kwon Soim,
Lee Eun Sook,
Yoon Sungpil
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.05.039
Subject(s) - socs3 , cytoplasm , nuclear localization sequence , chromosomal translocation , nucleus , microbiology and biotechnology , socs2 , nuclear transport , nuclear protein , cell nucleus , nuclear export signal , biology , proteasome , chemistry , stat3 , gene , signal transduction , biochemistry , transcription factor , suppressor
We investigated the cellular localization of ectopically‐expressed CIS, SOCS1, SOCS2 and SOCS3 proteins. We found that SOCS proteins localize to the nucleus where they reduce Stat3 proteins and that the presence of proteasome inhibitors increased SOCS nuclear localization. Our results indicate that increased nuclear localization resulted from increased levels of SOCS proteins in the cytoplasm. Finally, we demonstrate that the same effect occurs with endogenously‐expressed SOCS proteins. These observations suggest that increased cytoplasmic levels of proteins in the SOCS family are regulated through nuclear translocation.