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TRPV1‐null mice are protected from diet‐induced obesity
Author(s) -
Motter Arianne L.,
Ahern Gerard P.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.05.021
Subject(s) - trpv1 , medicine , endocrinology , capsaicin , transient receptor potential channel , calcitonin gene related peptide , receptor , chemistry , obesity
We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild‐type and TRPV1‐null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1‐null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild‐type and TRPV1‐null mice were ∼51 and 34 g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1‐null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3‐L1 preadipocytes expressed functional calcitonin gene‐related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1‐sensitive sensory nerves may regulate energy and fat metabolism.