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cAMP regulates respiration and oxidative stress during rehydration in Anabaena sp. PCC 7120
Author(s) -
Higo Akiyoshi,
Ikeuchi Masahiko,
Ohmori Masayuki
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.05.007
Subject(s) - oxidative phosphorylation , oxidative stress , adenylate kinase , respiration , biochemistry , chemistry , lipid peroxidation , protein carbonylation , wild type , cyclase , anabaena , cellular respiration , biology , mitochondrion , gene , bacteria , botany , enzyme , cyanobacteria , genetics , mutant
Cellular cAMP level increased dramatically upon rehydration following dehydration for 24 h in Anabaena sp. PCC 7120, but not in disruptant of an adenylate cyclase gene, cyaC . Oxygen consumption in the cyaC disruptant upon rehydration was higher than that in wild‐type strain. Determination of lipid peroxidation and protein carbonylation of the cells revealed greater oxidative stress in the cyaC disruptant than in the wild‐type strain during rehydration. Addition of cAMP or KCN to the cyaC disruptant decreased cellular oxygen consumption upon rehydration and oxidative damage. These results suggest that respiration upon rehydration is regulated by cAMP and that the higher respiration activity results in more oxidative damage in cyaC disruptant.