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Autocrine motility factor stimulates the invasiveness of malignant cells as well as up‐regulation of matrix metalloproteinase‐3 expression via a MAPK pathway
Author(s) -
Haga Arayo,
Funasaka Tatsuyoshi,
Deyashiki Yoshihiro,
Raz Avraham
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.05.005
Subject(s) - mapk/erk pathway , autocrine signalling , mmp3 , mapk cascade , motility , microbiology and biotechnology , kinase , phosphorylation , matrix metalloproteinase , protein kinase a , signal transduction , biology , cell culture , chemistry , cancer research , gene expression , biochemistry , gene , genetics
The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase‐3 (MMP3). The increase in MMP3 was found in an AMF‐high production tumor cell line, and c‐Jun, c‐Fos and mitogen‐activated protein kinases (MAPKs) were also highly phosphorylated compared with the parent line. AMF stimulation induced the rapid phosphorylation of the cellular MAPK cascade and MMP3 secretion, which was blocked using a specific MAPK inhibitor. Results of this study suggest that AMF stimulation stimulates MMP3 expression via a MAPK signaling pathway.