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The nuclear envelope as an integrator of nuclear and cytoplasmic architecture
Author(s) -
Crisp Melissa,
Burke Brian
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.05.001
Subject(s) - cytoplasm , envelope (radar) , nucleus , nuclear lamina , cytoskeleton , container (type theory) , microbiology and biotechnology , architecture , integrator , computational biology , cell nucleus , nuclear protein , biophysics , biology , chemistry , computer science , genetics , cell , materials science , gene , transcription factor , telecommunications , computer network , radar , bandwidth (computing) , art , visual arts , composite material
Initially perceived as little more than a container for the genome, our view of the nuclear envelope (NE) and its role in defining global nuclear architecture has evolved significantly in recent years. The recognition that certain human diseases arise from defects in NE components has provided new insight into its structural and regulatory functions. In particular, NE defects associated with striated muscle disease have been shown to cause structural perturbations not just of the nucleus itself but also of the cytoplasm. It is now becoming increasingly apparent that these two compartments display co‐dependent mechanical properties. The identification of cytoskeletal binding complexes that localize to the NE now reveals a molecular framework that can seamlessly integrate nuclear and cytoplasmic architecture.