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Providing cellular signposts – Post‐translational modifications of intermediate filaments
Author(s) -
Hyder Claire L.,
Pallari Hanna-Mari,
Kochin Vitaly,
Eriksson John E.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.064
Subject(s) - intermediate filament , protein filament , posttranslational modification , phosphorylation , microbiology and biotechnology , chemistry , function (biology) , biophysics , biology , cytoskeleton , biochemistry , cell , enzyme
Intermediate filaments are dynamically regulated by their post‐translational modifications. Initially these modifications were found to regulate filament dynamics and organization. In the last few years, their roles have extended significantly to facilitating, for example, the recruitment and sequestration of signaling molecules that regulate a wide range of cellular functions. While phosphorylation has been established as the principal post‐translational modification regulating intermediate filament function, other modifications with co‐operative roles are emerging, adding a further dimensions to intermediate filament‐mediated signaling.