Co‐regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac | Zendy

Selvakumar Balakrishnan | Zendy; Hess Douglas T. | Zendy; Goldschmidt-Clermont Pascal J. | Zendy; Stamler Jonathan S. | Zendy

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Co‐regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac

Author(s) -

Selvakumar Balakrishnan,

Hess Douglas T.,

Goldschmidt-Clermont Pascal J.,

Stamler Jonathan S.

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.04.062

Subject(s) - microbiology and biotechnology , nitric oxide , signal transduction , nadph oxidase , gtpase , small gtpase , reactive oxygen species , rac gtp binding proteins , rac1 , chemistry , cytoskeleton , actin cytoskeleton , biochemistry , biology , cell , organic chemistry

Nitric oxide (NO), generated by NO synthases (NOSs), has multifarious roles in signal transduction. Reactive oxygen species (ROS), generated by ubiquitous NADPH oxidases (NOXs), also participate in cellular signaling. However, the coordination of signals conveyed by NO and ROS is poorly understood. We show that the small GTPase Rac, a component of some NOXs, also interacts with and regulates the constitutively‐expressed NOSs. Cellular NO andO 2 ‐production increase or decrease together following activation or inhibition of Rac, and Rac inhibition reveals transduction mechanisms that depend upon NO (vasodilation), ROS (actin polymerization) or both (cytoskeletal organization). Thus, signaling by NO and ROS may be coordinated through a common control element.

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