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The antioxidant properties of serum albumin
Author(s) -
Roche Marjolaine,
Rondeau Philippe,
Singh Nihar Ranjan,
Tarnus Evelyne,
Bourdon Emmanuel
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.057
Subject(s) - albumin , antioxidant , glycation , chemistry , biochemistry , oxidative stress , oxidative damage , serum albumin , radical , oxidative phosphorylation , receptor
Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical‐associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical‐trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported.