Arginine methylation of hnRNP K enhances p53 transcriptional activity | Zendy

Chen Yibin | Zendy; Zhou Xinyuan | Zendy; Liu Na | Zendy; Wang Chaochen | Zendy; Zhang Liang | Zendy; Mo Wei | Zendy; Hu Gengxi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Arginine methylation of hnRNP K enhances p53 transcriptional activity

Author(s) -

Chen Yibin,

Zhou Xinyuan,

Liu Na,

Wang Chaochen,

Zhang Liang,

Mo Wei,

Hu Gengxi

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.04.051

Subject(s) - methylation , arginine , dna methylation , microbiology and biotechnology , chemistry , dna , biology , biochemistry , gene expression , amino acid , gene

Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research