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A novel anticancer effect of butein: Inhibition of invasion through the ERK1/2 and NF‐κB signaling pathways in bladder cancer cells
Author(s) -
Zhang LiRui,
Chen Wei,
Li Xu
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.046
Subject(s) - cancer research , cancer cell , epithelial–mesenchymal transition , nf κb , metastasis , signal transduction , cancer , chemistry , bladder cancer , cell growth , microbiology and biotechnology , biology , medicine , biochemistry
There is increasing evidence that epithelial–mesenchymal transition (EMT) plays a critical role in cancer metastasis. Butein is a polyphenolic compound, which has been found to exhibit anti‐proliferation effects on cancer cells. Here, we report that in addition to its function as an anti‐proliferation agent, butein can inhibit migration and invasion through the ERK1/2 and NF‐κB signaling pathways in human bladder cancer cells, and this inhibitory effect may be associated with reversal of EMT. These results were further confirmed by RNAi‐mediated suppression of NF‐κB, which partly reverses EMT and inhibits cell invasive ability in vitro. These results suggest a novel function of butein as an invasion inhibitor in bladder cancer.