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Acyclic retinoid inhibits functional interaction of transcription factors Krüppel‐like factor 5 and retinoic acid receptor‐alpha
Author(s) -
Kada Nanae,
Suzuki Toru,
Aizawa Kenichi,
Munemasa Yoshiko,
Matsumura Takayoshi,
Sawaki Daigo,
Nagai Ryozo
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.040
Subject(s) - transactivation , krüppel , transcription factor , retinoic acid , retinoid , retinoid x receptor alpha , retinoid x receptor , immunoprecipitation , cancer research , chemistry , biology , microbiology and biotechnology , biochemistry , nuclear receptor , gene
We show that transcription factor Krüppel‐like factor 5 (KLF5), which is important in cardiovascular remodeling, interacts with retinoic acid receptor‐alpha (RARα) to regulate downstream gene expression. Here, we investigated whether acyclic retinoid (ACR) regulates KLF5 and inhibits vascular remodeling. Co‐immunoprecipitation and pull‐down binding assay showed that ACR attenuates functional interaction of KLF5 and RARα. ACR affects KLF5 functions by regulating transactivation of platelet‐derived growth factor A (PDGF‐A) chain. ACR may be a new vascular therapy to target KLF5 in cardiovascular pathology.