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Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes
Author(s) -
Weigert Johanna,
Neumeier Markus,
Wanninger Josef,
Wurm Sylvia,
Kopp Andrea,
Schober Franziska,
Filarsky Michael,
Schäffler Andreas,
Zeitoun Martina,
Aslanidis Charalampos,
Buechler Christa
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.031
Subject(s) - adiponectin , adipokine , adiponectin receptor 1 , medicine , endocrinology , type 2 diabetes , receptor , overweight , monocyte , diabetes mellitus , chemistry , obesity , insulin resistance
The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal‐weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal‐weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal‐weight donors. Induction of IL‐6 and IL‐8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes.