Premium
Nuclear functions in space and time: Gene expression in a dynamic, constrained environment
Author(s) -
Trinkle-Mulcahy Laura,
Lamond Angus I.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.029
Subject(s) - gene expression , expression (computer science) , computational biology , gene , regulation of gene expression , space (punctuation) , computer science , genetics , biology , programming language , operating system
All eukaryotic cells enclose their genome within a dedicated, membrane‐bound organelle termed the nucleus, which functions to partition gene transcription from sites of protein translation in the cytoplasm. Despite a great deal of research effort, basic questions about chromosome structure and gene expression mechanisms remain to be answered, including the relationship between the spatial organization of the genome and the transcription machinery. Powerful in vivo approaches are allowing researchers to test established in vitro concepts within the dynamic cellular environment, while genome‐wide screens have enabled rapid high throughput analyses of both structural and functional parameters. In several cases, as highlighted here, this has turned up surprising results and has forced a re‐evaluation of models for nuclear structure and gene regulation.