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Evidence for multiple peroxisome proliferator‐activated receptor γ transcripts in bone: Fine‐tuning by hormonal regulation and mRNA stability
Author(s) -
Bruedigam Claudia,
Koedam Marijke,
Chiba Hideki,
Eijken Marco,
van Leeuwen Johannes P.T.M.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.012
Subject(s) - peroxisome proliferator activated receptor gamma , downregulation and upregulation , peroxisome proliferator activated receptor , receptor , messenger rna , peroxisome , medicine , endocrinology , signal transduction , microbiology and biotechnology , chemistry , biology , biochemistry , gene
The expression, regulation and functional significance of multiple peroxisome proliferator‐activated receptor γ transcript variants in bone were studied. PPARG transcripts giving rise to PPARg‐1 protein were expressed in human osteoblasts, whereas PPARG‐2 transcript and protein remained virtually absent. PPARG expression underwent homologous regulation, was upregulated during differentiation and directly induced by the osteogenic hormone dexamethasone, suggesting a role for PPARg‐1 in osteogenesis. Differences between the stabilities of PPARG‐1, ‐3 and ‐4 were observed. We hypothesize that cell‐specific expression patterns of multiple PPARG transcript variants encoding for the same protein but differing in mRNA stabilities enable a fine‐tuning of PPARG action, which eventually supports a well‐adjusted signal transduction between the cell and its environment.