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Actin in the endocytic pathway: From yeast to mammals
Author(s) -
Girao Henrique,
Geli Maria-Isabel,
Idrissi Fatima-Zahra
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.04.011
Subject(s) - endocytic cycle , endocytosis , microbiology and biotechnology , endosome , internalization , biology , actin , yeast , clathrin , vacuole , actin remodeling , actin cytoskeleton , cell , cytoskeleton , biochemistry , cytoplasm , intracellular
Genetic analysis of endocytosis in yeast early pointed to the essential role of actin in the uptake step. Efforts to identify the machinery involved demonstrated the important contribution of Arp2/3 and the myosins‐I. Analysis of the process using live‐cell fluorescence microscopy and electron microscopy have recently contributed to refine molecular models explaining clathrin and actin‐dependent endocytic uptake. Increasing evidence now also indicates that actin plays important roles in post‐internalization events along the endocytic pathway in yeast, including transport of vesicles, motility of endosomes and vacuole fusion. This review describes the present knowledge state on the roles of actin in endocytosis in yeast and points to similarities and differences with analogous processes in mammals.