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Extracellular transglutaminase 2 activates β‐catenin signaling in calcifying vascular smooth muscle cells
Author(s) -
Faverman Lidia,
Mikhaylova Lyudmila,
Malmquist Jennifer,
Nurminskaya Maria
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.03.053
Subject(s) - tissue transglutaminase , vascular smooth muscle , extracellular , extracellular matrix , microbiology and biotechnology , calcification , signal transduction , chemistry , biology , biochemistry , endocrinology , medicine , smooth muscle , enzyme
Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3‐fold increase in matrix mineralization and up‐regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related‐protein 5 receptor and activates β‐catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the β‐catenin signaling pathway.