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Regulation of mRNP dynamics along the export pathway
Author(s) -
Iglesias Nahid,
Stutz Françoise
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.03.038
Subject(s) - messenger rna , microbiology and biotechnology , transcription (linguistics) , rna processing , rna binding protein , gene expression , rna , biology , atpase , chemistry , gene , genetics , biochemistry , enzyme , linguistics , philosophy
The transcription of mRNA is tightly coupled to the concomitant recruitment of mRNA processing and export factors, resulting in the formation of mature and export competent mRNP complexes. This interconnection in gene expression implies extensive spatio‐temporal control of mRNP dynamics to prevent mRNA export factors bound to pre‐mRNA from functioning at the incorrect time and exporting nascent or incompletely processed pre‐mRNAs. Recent discoveries provide molecular understanding of how a broad range of post‐translational modifications together with RNA‐dependent ATPases coordinate proteins acting at different steps and regulate mRNP assembly and export.