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RNA‐binding proteins and post‐transcriptional gene regulation
Author(s) -
Glisovic Tina,
Bachorik Jennifer L.,
Yong Jeongsik,
Dreyfuss Gideon
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.03.004
Subject(s) - rna binding protein , intron , ribonucleoprotein , biology , rna , microbiology and biotechnology , biogenesis , heterogeneous ribonucleoprotein particle , gene expression , regulation of gene expression , gene , post transcriptional regulation , genetics , computational biology
RNAs in cells are associated with RNA‐binding proteins (RBPs) to form ribonucleoprotein (RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play critical roles in their biogenesis, stability, function, transport and cellular localization. Eukaryotic cells encode a large number of RBPs (thousands in vertebrates), each of which has unique RNA‐binding activity and protein–protein interaction characteristics. The remarkable diversity of RBPs, which appears to have increased during evolution in parallel to the increase in the number of introns, allows eukaryotic cells to utilize them in an enormous array of combinations giving rise to a unique RNP for each RNA. In this short review, we focus on the RBPs that interact with pre‐mRNAs and mRNAs and discuss their roles in the regulation of post‐transcriptional gene expression.