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Nuclear pore complex assembly through the cell cycle: Regulation and membrane organization
Author(s) -
Antonin Wolfram,
Ellenberg Jan,
Dultz Elisa
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.067
Subject(s) - nuclear pore , biogenesis , cytoplasm , microbiology and biotechnology , nucleoporin , nucleus , membrane , inner membrane , nuclear membrane , cell nucleus , chemistry , cell , biophysics , nuclear transport , biology , biochemistry , gene
In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in cells. Although their composition in yeast and metazoa is well characterized, understanding how NPCs are assembled and form the pore through the double membrane of the nuclear envelope and how both processes are controlled still remains a challenge. Here, we summarize what is known about the biogenesis of NPCs throughout the cell cycle with special focus on the membrane reorganization and the regulation that go along with NPC assembly.