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Cell responses regulated by early reorganization of actin cytoskeleton
Author(s) -
Papakonstanti E.A.,
Stournaras C.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.064
Subject(s) - microbiology and biotechnology , actin remodeling , microfilament , actin , actin remodeling of neurons , cytoskeleton , actin cytoskeleton , mdia1 , extracellular , actin binding protein , profilin , chemistry , biophysics , biology , cell , biochemistry
Microfilaments exist in a dynamic equilibrium between monomeric and polymerized actin and the ratio of monomers to polymeric forms is influenced by a variety of extracellular stimuli. The polymerization, depolymerization and redistribution of actin filaments are modulated by several actin‐binding proteins, which are regulated by upstream signalling molecules. Actin cytoskeleton is involved in diverse cellular functions including migration, ion channels activity, secretion, apoptosis and cell survival. In this review we have outlined the role of actin dynamics in representative cell functions induced by the early response to extracellular stimuli.