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Retracted : Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury
Author(s) -
Knight Richard A.,
Chen-Scarabelli Carol,
Yuan Zhaokan,
McCauley Roy B.,
Di Rezze J.,
Scarabelli Gabriele M.,
Townsend Paul A.,
Latchman David,
Saravolatz Louis,
Faggian Giuseppe,
Mazzucco Alessandro,
Chowdrey Hardial S.,
Stephanou Anastasis,
Scarabelli Tiziano M.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.035
Subject(s) - urocortin , ischemia , medicine , myocyte , cardiac myocyte , programmed cell death , apoptosis , necrosis , endocrinology , cardiology , biology , receptor , biochemistry
This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. Urocortin levels rose after 5‐min ischemia and peaked after 10‐min ischemia, when cell death was not detected. However, myocyte apoptosis and/or necrosis occurred following 20‐ and 30‐min ischemia, which paralleled a fall in urocortin levels, suggesting that urocortin expression and release are mainly sustained by metabolically challenged, though still viable myocytes. Hence, since cardiac release of urocortin, unlike that of conventional biomarkers, occurs before and apart from cell death, urocortin levels may be clinically useful in the diagnosis of sublethal myocardial ischemia.