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A careful disorderliness in the proteome: Sites for interaction and targets for future therapies
Author(s) -
Russell Robert B.,
Gibson Toby J.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.027
Subject(s) - proteome , computational biology , function (biology) , protein function , focus (optics) , phenomenon , data science , biology , computer science , bioinformatics , epistemology , evolutionary biology , physics , genetics , philosophy , optics , gene
The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein–protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules.