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Shaping dots and lines: Adding modularity into protein interaction networks using structural information
Author(s) -
Campagna Anne,
Serrano Luis,
Kiel Christina
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.019
Subject(s) - modularity (biology) , modular design , protein interaction networks , computer science , protein–protein interaction , interaction network , binding affinities , interaction information , scale (ratio) , biological system , process (computing) , computational biology , distributed computing , theoretical computer science , chemistry , biology , mathematics , physics , genetics , receptor , statistics , quantum mechanics , gene , operating system , biochemistry
Determining protein interaction networks and generating models to simulate network changes in time and space are crucial for understanding a biological system and for predicting the effect of mutants found in diseases. In this review we discuss the great potential of using structural information together with computational tools towards reaching this goal: the prediction of new protein interactions, the estimation of affinities and kinetic rate constants between protein complexes, and finally the determination of which interactions are compatible with each other and which interactions are exclusive. The latter one will be important to reorganize large scale networks into functional modular networks.