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Co‐evolution and co‐adaptation in protein networks
Author(s) -
Juan David,
Pazos Florencio,
Valencia Alfonso
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.017
Subject(s) - adaptation (eye) , phylogenetic tree , similarity (geometry) , tree (set theory) , evolutionary biology , biology , computational biology , computer science , mathematics , genetics , artificial intelligence , gene , neuroscience , combinatorics , image (mathematics)
Interacting or functionally related proteins have been repeatedly shown to have similar phylogenetic trees. Two main hypotheses have been proposed to explain this fact. One involves compensatory changes between the two protein families (co‐adaptation). The other states that the tree similarity may be an indirect consequence of the involvement of the two proteins in similar cellular process, which in turn would be reflected by similar evolutionary pressure on the corresponding sequences. There are published data supporting both propositions, and currently the available information is compatible with both hypotheses being true, in an scenario in which both sets of forces are shaping the tree similarity at different levels.