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Interaction networks for systems biology
Author(s) -
Bader Samuel,
Kühner Sebastian,
Gavin Anne-Claude
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.015
Subject(s) - systems biology , computational biology , protein interaction networks , protein–protein interaction , biology , biological network , structural biology , computer science , genetics
Cellular functions are almost always the result of the coordinated action of several proteins, interacting in protein complexes, pathways or networks. Progress made in devising suitable tools for analysis of protein–protein interactions, have recently made it possible to chart interaction networks on a large‐scale. The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics.