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Metastasis tumor antigen 1 is involved in the resistance to heat stress‐induced testicular apoptosis
Author(s) -
Li Wei,
Bao Wei,
Ma Jing,
Liu Xinping,
Xu Ruojun,
Wang Rui-an,
Zhang Yuanqiang
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.013
Subject(s) - apoptosis , heat stress , heat resistance , antigen , metastasis , cancer research , chemistry , microbiology and biotechnology , medicine , biology , immunology , cancer , materials science , biochemistry , composite material , zoology
Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregualtion of p53 in mouse cryptorchidism. Furthermore, in vitro over‐expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat‐induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.