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Oxidation by hypochlorite converts protective HDL into a potent platelet agonist
Author(s) -
Assinger Alice,
Schmid Werner,
Eder Sandra,
Schmid Diethart,
Koller Elisabeth,
Volf Ivo
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.02.001
Subject(s) - cd36 , scavenger receptor , chemistry , platelet , hypochlorite , thrombospondin , platelet activation , agonist , scavenger , biochemistry , calcium in biology , pharmacology , intracellular , receptor , lipoprotein , medicine , radical , cholesterol , enzyme , inorganic chemistry , metalloproteinase
Addition of hypochlorite‐oxidized HDL to human platelets results in an immediate and transient raise in intracellular calcium, surface expression of P‐selectin and platelet aggregation. The observed effects are dose dependent and can be blocked by an antibody directed against the lipoprotein‐binding domain of platelet thrombospondin‐ and scavenger receptor CD36.