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Multiple effects of acetaminophen and p38 inhibitors: Towards pathway toxicology
Author(s) -
Xu Jinghai J.,
Hendriks Bart S.,
Zhao Jie,
de Graaf David
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.063
Subject(s) - acetaminophen , signalling pathways , computational biology , biological pathway , drug discovery , pharmacology , toxicology , chemistry , biology , bioinformatics , signal transduction , biochemistry , gene expression , gene
The majority of drug‐related toxicities are idiosyncratic, with little pathophysiological insight and mechanistic understanding. Pathway toxicology is an emerging field of toxicology in the post‐genomic era that studies the molecular interactions between toxicants and biological pathways as a way to bridge this knowledge gap. Using two case studies – acetaminophen and p38 MAPK inhibitors – this review illustrates how a pathway‐based perspective has advanced our understanding of compound and target‐based toxicities. The advancement of pathway toxicology will be dependent on integrated applications of techniques from basic sciences and a fundamental understanding of the interdependence of multiple biological pathways in living organisms.