Angiotensin II and III suppress food intake via angiotensin AT 2  receptor and prostaglandin EP 4  receptor in mice | Zendy

Ohinata Kousaku | Zendy; Fujiwara Yoko | Zendy; Fukumoto Shingo | Zendy; Iwai Masaru | Zendy; Horiuchi Masatsugu | Zendy; Yoshikawa Masaaki | Zendy

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Angiotensin II and III suppress food intake via angiotensin AT 2 receptor and prostaglandin EP 4 receptor in mice

Author(s) -

Ohinata Kousaku,

Fujiwara Yoko,

Fukumoto Shingo,

Iwai Masaru,

Horiuchi Masatsugu,

Yoshikawa Masaaki

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.01.054

Subject(s) - receptor , knockout mouse , endocrinology , angiotensin ii , medicine , receptor antagonist , chemistry , antagonist , prostaglandin , angiotensin receptor , pharmacology , biology

Intracerebroventricularly administered angiotensin (Ang) II and III dose‐dependently suppressed food intake in mice and their anorexigenic activities were inhibited by AT 2 receptor‐selective antagonist. Ang II did not suppress food intake in AT 2 receptor‐knockout mice, while it did significantly in wild‐type and AT 1 receptor‐knockout mice. The suppression of food intake in AT 1 receptor‐knockout mice was smaller than that in wild‐type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP 4 receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT 2 receptor with partial involvement of AT 1 receptor, followed by EP 4 receptor activation, which is a novel pathway regulating food intake.

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