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Angiotensin II and III suppress food intake via angiotensin AT 2 receptor and prostaglandin EP 4 receptor in mice
Author(s) -
Ohinata Kousaku,
Fujiwara Yoko,
Fukumoto Shingo,
Iwai Masaru,
Horiuchi Masatsugu,
Yoshikawa Masaaki
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.054
Subject(s) - receptor , knockout mouse , endocrinology , angiotensin ii , medicine , receptor antagonist , chemistry , antagonist , prostaglandin , angiotensin receptor , pharmacology , biology
Intracerebroventricularly administered angiotensin (Ang) II and III dose‐dependently suppressed food intake in mice and their anorexigenic activities were inhibited by AT 2 receptor‐selective antagonist. Ang II did not suppress food intake in AT 2 receptor‐knockout mice, while it did significantly in wild‐type and AT 1 receptor‐knockout mice. The suppression of food intake in AT 1 receptor‐knockout mice was smaller than that in wild‐type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP 4 receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT 2 receptor with partial involvement of AT 1 receptor, followed by EP 4 receptor activation, which is a novel pathway regulating food intake.