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Structural features of protein folding nuclei
Author(s) -
Garbuzynskiy S.O.,
Kondratova M.S.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.049
Subject(s) - protein folding , nucleus , folding (dsp implementation) , chemistry , biophysics , phi value analysis , structural motif , crystallography , protein structure , biochemistry , biology , microbiology and biotechnology , engineering , electrical engineering
A crucial event of protein folding is the formation of a folding nucleus. We demonstrate the presence of a considerable coincidence between the location of folding nuclei and the location of so‐called “root structural motifs”, which have unique overall folds and handedness. In the case of proteins with a single root structural motif, the involvement in the formation of a folding nucleus is in average significantly higher for amino acids residues that are in root structural motifs, compared to residues in other parts of the protein. The tests carried out revealed that the observed difference is statistically reliable. Thus, a structural feature that corresponds to the protein folding nucleus is now found.