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Activation of NO donors in mitochondria: Peroxidase metabolism of (2‐hydroxyamino‐vinyl)‐triphenyl‐phosphonium by cytochrome c releases NO and protects cells against apoptosis
Author(s) -
Stoyanovsky Detcho A.,
Vlasova Irina I.,
Belikova Natalia A.,
Kapralov Alexandr,
Tyurin Vladimir,
Kagan Valerian E.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.047
Subject(s) - chemistry , phosphonium , mitochondrion , peroxidase , cytochrome c , apoptosis , metabolism , biochemistry , enzyme , polymer chemistry
In mitochondrial apoptosis, the formation of cytochrome c –cardiolipin complex ([CL‐cyt c ]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2‐hydroxyamino‐vinyl)‐triphenyl‐phosphonium (HVTP), which compartmentalizes exclusively into mitochondria, undergoes a [CL‐cyt c ]‐catalyzed bioactivation to nitric oxide (NO), inhibits peroxidase activity, and protects cells from apoptosis.