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Antimicrobial properties of avian eggshell‐specific C‐type lectin‐like proteins
Author(s) -
Wellman-Labadie Olivier,
Lakshminarayanan Rajamani,
Hincke Maxwell T.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.043
Subject(s) - lectin , antimicrobial , microbiology and biotechnology , bacillus subtilis , c type lectin , biology , staphylococcus aureus , eggshell , biochemistry , bacteria , ecology , genetics
C‐type lectin‐like proteins are major components of the calcified eggshell of multiple avian species. In this study, two representative avian C‐type lectin‐like proteins, ovocleidin‐17 and ansocalcin, were purified from decalcified chicken and goose eggshell protein extracts and investigated for carbohydrate binding activity as well as antimicrobial activity. Purified ovocleidin‐17 and ansocalcin were found to bind bacterial polysaccharides, and were bactericidal against Bacillus subtilis , Staphylococcus aureus and Pseudomona aeruginosa . Bactericidal activity was found to be enhanced in the presence of calcium but was not dependent on its presence. The results suggest that avian C‐type lectin‐like proteins may play an important antimicrobial role in defence of the avian embryo.