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Serum amyloid A‐induced IL‐6 production by rheumatoid synoviocytes
Author(s) -
Koga Tomohiro,
Torigoshi Takafumi,
Motokawa Satoru,
Miyashita Taichiro,
Maeda Yumi,
Nakamura Minoru,
Komori Atsumasa,
Aiba Yoshihiro,
Uemura Takashi,
Yatsuhashi Hiroshi,
Ishibashi Hiromi,
Eguchi Katsumi,
Migita Kiyoshi
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.01.022
Subject(s) - serum amyloid a , amyloid (mycology) , chemistry , production (economics) , immunology , medicine , inflammation , pathology , economics , macroeconomics
In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin‐6 (IL‐6) using rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLS). Recombinant SAA stimulation induced the production of pro‐inflammatory cytokine, IL‐6, from RA‐FLS. The signaling events induced by SAA included the activation of the mitogen‐activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor‐kappa B (NF‐κB). Inhibitor studies have shown SAA‐induced IL‐6 production to be down‐regulated by NF‐κB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL‐6, which is critically involved in RA pathogenesis.