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Modulation of nucleobindin‐1 and nucleobindin‐2 by caspases
Author(s) -
Valencia C. Alexander,
Cotten Steven W.,
Duan Jinzhu,
Liu Rihe
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.12.019
Subject(s) - modulation (music) , chemistry , microbiology and biotechnology , caspase , apoptosis , biology , biochemistry , physics , programmed cell death , acoustics
Nucleobindin‐1 (NUCB1) and nucleobindin‐2 (NUCB2) are multifunctional proteins that interact with Ca 2+ , nucleic acids and various regulatory proteins in different signaling pathways. So far, our understanding of the regulation of the biological functions of nucleobindins remains limited. In our proteome‐wide selection for downstream caspase substrates, both NUCB1 and NUCB2 are found to be the downstream substrates of caspases. We report here the detailed analyses of the cleavage of nucleobindins by caspases. Significantly, the caspase cleavage sites are located exactly at one of the Ca 2+ ‐binding EF‐hand motifs. Our results suggest that the functions of nucleobindins could be modulated by caspase‐mediated cleavage in apoptosis.