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Induction of trophinin in human endometrial surface epithelia by CGβ and IL‐1β
Author(s) -
Sugihara Kazuhiro,
Kabir-Salmani Maryam,
Byrne James,
Wolf Don P.,
Lessey Bruce,
Iwashita Mitsutoshi,
Aoki Daisuke,
Nakayama Jun,
Fukuda Michiko N.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.12.001
Subject(s) - chemistry , andrology , microbiology and biotechnology , biology , medicine
During embryo implantation, trophinin mediates cell adhesion by homophilic binding at the apical surfaces of trophectoderm and endometrium. Trophinin is expressed on the human endometrial epithelia in rare occasions. We developed hCG‐coated agarose beads that mimic the physical and physiological features of an implantation‐stage human blastocyst. When hCG‐coated beads were applied to human endometrial epithelial cells in the presence of IL‐1β, endometrial cells acquired strong trophinin expression and the ability for apical cell adhesion with trophinin‐expressing human trophoblastic cells. These results provide a mechanism for trophinin‐mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst.