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The heretotrimeric G protein subunit Gαi is present on mitochondria
Author(s) -
Lyssand John S.,
Bajjalieh Sandra M.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.11.044
Subject(s) - protein subunit , g protein , immunolabeling , microbiology and biotechnology , mitochondrion , receptor , chemistry , intracellular , biochemistry , biology , signal transduction , gene , immunohistochemistry , immunology
Receptors that signal through heretotrimeric GTP binding (G) proteins mediate the majority of intercellular communication. Recent evidence suggests that receptors acting through G proteins also transfer signals across the nuclear membrane. Here we present cell fractionation and immunolabeling data showing that the heretotrimeric G protein subunit Gαi is associated with mitochondria. This finding suggests that G protein receptor signaling may be a feature common to all membranes.