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Taurine increases cell proliferation and generates an increase in [Mg 2+ ] i accompanied by ERK 1/2 activation in human osteoblast cells
Author(s) -
Jeon Seol-Hee,
Lee Mun-Young,
Kim Shang-Jin,
Joe Sung-Gun,
Kim Gi-Beum,
Kim In-Shik,
Kim Nam-Soo,
Hong Chul-Un,
Kim Sung-Zoo,
Kim Jin-Shang,
Kang Hyung-Sub
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.11.035
Subject(s) - taurine , mapk/erk pathway , osteoblast , endocrinology , medicine , chemistry , cell growth , cell culture , microbiology and biotechnology , biology , biochemistry , phosphorylation , in vitro , amino acid , genetics
Taurine has been reported to influence bone metabolism, and its specific transport system, the taurine transporter, is expressed in osteoblasts. The mean [Mg 2+ ] i was 0.51 ± 0.01 mM in normal culture media. Taurine caused an increase in [Mg 2+ ] i by 0.72 ± 0.04 mM in human osteoblast (HOB) cells. This increment in [Mg 2+ ] i was inhibited significantly by PD98059, nifedipine, lidocaine, and imipramine. Taurine was also shown to stimulate the activation of ERK 1/2. This taurine‐stimulated ERK 1/2 activation was inhibited by PD98059. In the present study, taurine was shown to increase cell proliferation and generate an increase in [Mg 2+ ] i accompanied by ERK 1/2 activation in HOB cells.