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Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease
Author(s) -
Hardie D. Grahame
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.11.018
Subject(s) - ampk , metformin , anabolism , protein kinase a , amp activated protein kinase , catabolism , endocrinology , medicine , metabolic syndrome , type 2 diabetes , diabetes mellitus , chemistry , kinase , biochemistry , metabolism
Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy balance, which the AMP‐activated protein kinase (AMPK) regulates both at the cellular and whole body levels. AMPK switches cells from an anabolic state where nutrients are taken up and stored, to a catabolic state where they are oxidized. Drugs that activate AMPK indirectly (metformin and thiazolidinediones) are now the mainstay of treatment for type 2 diabetes, but more direct AMPK activators may have fewer side effects. However, activating mutations in AMPK can cause heart disease, and it will be important to look for adverse effects in the heart.