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Nuclear receptors: Decoding metabolic disease
Author(s) -
Sonoda Junichiro,
Pei Liming,
Evans Ronald M.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.11.016
Subject(s) - nuclear receptor , metabolic control analysis , transcription factor , biology , superfamily , dyslipidemia , metabolic pathway , receptor , disease , metabolic regulation , energy homeostasis , gene , bioinformatics , diabetes mellitus , biochemistry , computational biology , genetics , metabolism , endocrinology , medicine
Nuclear receptors (NR) are a superfamily of ligand‐activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here.