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The lipin protein family: Dual roles in lipid biosynthesis and gene expression
Author(s) -
Reue Karen,
Zhang Peixiang
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.11.014
Subject(s) - dual (grammatical number) , biosynthesis , gene , gene expression , microbiology and biotechnology , protein biosynthesis , protein expression , biochemistry , chemistry , genetics , biology , computational biology , art , literature
The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator‐activated receptor γ (PPARγ) coactivator‐1α and PPARα. Through these activities, the founding member of the family, lipin‐1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin‐2 and lipin‐3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.