CarO, an  Acinetobacter baumannii  outer membrane protein involved in carbapenem resistance, is essential for  l ‐ornithine uptake | Zendy

Mussi María A. | Zendy; Relling Verónica M. | Zendy; Limansky Adriana S. | Zendy; Viale Alejandro M. | Zendy

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CarO, an Acinetobacter baumannii outer membrane protein involved in carbapenem resistance, is essential for l ‐ornithine uptake

Author(s) -

Mussi María A.,

Relling Verónica M.,

Limansky Adriana S.,

Viale Alejandro M.

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.10.063

Subject(s) - ornithine , acinetobacter baumannii , arginine , microbiology and biotechnology , histidine , lysine , imipenem , chemistry , bacterial outer membrane , amino acid , bacteria , biochemistry , biology , antibiotics , antibiotic resistance , escherichia coli , pseudomonas aeruginosa , gene , genetics

We previously associated the emergence of carbapenem resistance in Acinetobacter baumannii with the loss of an outer membrane (OM) protein designated CarO. CarO was found essential for l ‐ornithine uptake: CarO‐deficient strains were specifically impaired to grow only on l ‐ornithine, and failed to incorporate l ‐[ 14 C] ornithine from the medium. l ‐arginine, and histidine and lysine to a lower extent, could effectively compete for l ‐[ 14 C] ornithine uptake. l ‐ornithine also reduced A. baumannii sensitivity to imipenem, suggesting that both compounds compete for uptake. The overall results indicate that CarO participates in the selective uptake of l ‐ornithine, carbapenems, and other basic amino acids in A. baumannii .

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